The Grand Cherokee debuted in grand fashion at the 1992 North American International Auto Show in Detroit, Michigan. Production of the Grand Cherokee started shortly afterward in the purpose-built Jefferson North Assembly in Detroit, Michigan and has remained there since.

ZJ (93-98) - The ZJ models, manufactured from 1993 to 1998, originally came in 3 general trims, the Base, Laredo, and the Limited. 1996 brought cosmetic changes ranging from improved body modeling (grille, bumpers), and integrated foglights; interior features added dual airbags and increased fabric quality for seating.

WJ (99-04) - The redesigned WJ 1999 Grand Cherokee shared just 127 parts with its predecessor. The structure was stiffened by Porsche Engineering for sharper steering and lighter weight. The spare tire was relocated from the side of the cargo compartment to under the floor to great relief of owners. The two heavy pushrod V8 engines were replaced by a single aluminum SOHC unit, Chrysler's then-new PowerTech. Although this engine produced less torque than both previous V8s, it was lighter and got much better fuel economy.

WK (05-Present) - The all-new WK Grand Cherokee debuted in 2004 for the 2005 model year. Features available for the first time in a Jeep included Quadra-Drive II four wheel drive and a rear-seat DVD player. The design still emphasizes power and luxury, with significant work done on improving noise, vibration, and harshness (NVH). However, for the first time, Jeep also emphasized on-road performance to a similar extent as the cornerstone of its brand, off-road capability.